Robert J Lake Selected Research

Cockayne Syndrome (Syndrome, Cockayne)

2/2022	Dynamic Interplay between Cockayne Syndrome Protein B and Poly(ADP-Ribose) Polymerase 1 during Oxidative DNA Damage Repair.
11/2018	Poly(ADP-ribose) polymerase 1 (PARP1) promotes oxidative stress-induced association of Cockayne syndrome group B protein with chromatin.
1/2018	Mechanistic insights into the regulation of transcription and transcription-coupled DNA repair by Cockayne syndrome protein B.
1/2017	NAP1L1 accelerates activation and decreases pausing to enhance nucleosome remodeling by CSB.
3/2016	The CSB chromatin remodeler and CTCF architectural protein cooperate in response to oxidative stress.
4/2014	The sequence-specific transcription factor c-Jun targets Cockayne syndrome protein B to regulate transcription and chromatin structure.
5/2013	Structure, function and regulation of CSB: a multi-talented gymnast.
4/2013	ATP-dependent chromatin remodeling by Cockayne syndrome protein B and NAP1-like histone chaperones is required for efficient transcription-coupled DNA repair.
10/2011	Reciprocally regulated chromatin association of Cockayne syndrome protein B and p53 protein.
1/2010	UV-induced association of the CSB remodeling protein with chromatin requires ATP-dependent relief of N-terminal autorepression.

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Robert J Lake Research Topics

Disease

10	Cockayne Syndrome (Syndrome, Cockayne) 02/2022 - 01/2010
3	Premature Aging 03/2016 - 04/2013
2	Neoplasms (Cancer) 01/2020 - 10/2011
1	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2020
1	Carcinogenesis 04/2011

Drug/Important Bio-Agent (IBA)

7	IgA receptor (protein B)IBA 02/2022 - 10/2011
6	Adenosine Triphosphate (ATP)IBA 11/2018 - 01/2010
6	ChromatinIBA 11/2018 - 01/2010
5	Proteins (Proteins, Gene)FDA Link 11/2018 - 10/2011
2	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 02/2022 - 11/2018
2	NucleotidesIBA 01/2018 - 01/2017
1	DNA (Deoxyribonucleic Acid)IBA 01/2020
1	Auranofin (Ridaura)FDA Link 01/2020
1	Adenosine Triphosphatases (ATPase)IBA 01/2018
1	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2016
1	Transcription Factors (Transcription Factor)IBA 04/2014
1	GTP-Binding Proteins (G-Protein)IBA 04/2014
1	ErbB Receptors (EGF Receptor)IBA 04/2014
1	Biological ProductsIBA 05/2013
1	Histone ChaperonesIBA 04/2013
1	Notch ReceptorsIBA 04/2011
1	LigandsIBA 04/2011